Shyh-Dar Li

Shyh-Dar Li (UBC Professor): Development of lipid and polymer based nanoparticles for targeted drug and nucleic acid delivery Development of child-friendly formulations Ocular drug delivery Drug delivery to the brain Sustained drug release formulations Needle free delivery of proteins Gene therapy and vaccine Drug discovery, design and delivery; Nano …

An efficient and low immunostimulatory nanoparticle

We have developed a nanoparticle formulation [liposomes-protamine-hyaluronic acid nanoparticle (LPH-NP)] for systemically delivering siRNA into the tumor. The LPH-NP was prepared in a self-assembling process. Briefly, protamine and a mixture of siRNA and hyaluronic acid were mixed to prepare a negat …